phosphatidylserine decarboxylase
Symbol
PISD
(may also be known as: None)
Organism
Human
Description
Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| psd-1 | Caenorhabditis elegans | |
| CG5991 | Drosophila melanogaster | |
| pisd | Danio rerio | |
| Gm20671 | Mus musculus | |
| Pisd | Rattus norvegicus | |
| PSD1 | Saccharomyces cerevisiae | |
| psd1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0008654 | phospholipid biosynthetic process | biological_process |
| GO:0005739 | mitochondrion | cellular_component |
| GO:0004609 | phosphatidylserine decarboxylase activity | molecular_function |
| GO:0016829 | lyase activity | molecular_function |