mitogen-activated protein kinase 8 interacting protein 2

Symbol

MAPK8IP2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]

Orthologs

SymbolSpecies
mapk8ip2 Danio rerio
Mapk8ip2 Mus musculus
Mapk8ip2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3737 Gene expression of MAPK8IP2 decreases with age Molecular skin Human MAPK8IP2 —

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0001662 behavioral fear response biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0007172 signal complex assembly biological_process
GO:0007254 JNK cascade biological_process
GO:0007617 mating behavior biological_process
GO:0010469 regulation of receptor activity biological_process
GO:0032874 positive regulation of stress-activated MAPK cascade biological_process
GO:0035176 social behavior biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0046328 regulation of JNK cascade biological_process
GO:0046958 nonassociative learning biological_process
GO:0048813 dendrite morphogenesis biological_process
GO:0051966 regulation of synaptic transmission, glutamatergic biological_process
GO:0060079 regulation of excitatory postsynaptic membrane potential biological_process
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity biological_process
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity biological_process
GO:0005737 cytoplasm cellular_component
GO:0014069 postsynaptic density cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043234 protein complex cellular_component
GO:0001540 beta-amyloid binding molecular_function
GO:0005078 MAP-kinase scaffold activity molecular_function
GO:0005198 structural molecule activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0019894 kinesin binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0030295 protein kinase activator activity molecular_function
GO:0032403 protein complex binding molecular_function