quinolinate phosphoribosyltransferase
Symbol
QPRT
(may also be known as: None)
Organism
Human
Description
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Qprt | Mus musculus | |
| Qprt | Rattus norvegicus | |
| BNA6 | Saccharomyces cerevisiae |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006766 | vitamin metabolic process | biological_process | |
| GO:0006767 | water-soluble vitamin metabolic process | biological_process | |
| GO:0009435 | NAD biosynthetic process | biological_process | |
| GO:0019363 | pyridine nucleotide biosynthetic process | biological_process | |
| GO:0019674 | NAD metabolic process | biological_process | |
| GO:0034213 | quinolinate catabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0046874 | quinolinate metabolic process | biological_process | |
| GO:0051259 | protein oligomerization | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |