fms-related tyrosine kinase 4

Symbol

FLT4 (may also be known as: None)

Organism

Human

Description

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ver-1 Caenorhabditis elegans
flt4 Danio rerio
Flt4 Mus musculus
Flt4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2714 Hypermethylation of FLT4 is positively correlated with age Molecular blood Human FLT4 —

GO Terms

GO IDGO TermGO Category
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0001944 vasculature development biological_process
GO:0001945 lymph vessel development biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0002040 sprouting angiogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0010575 positive regulation vascular endothelial growth factor production biological_process
GO:0010595 positive regulation of endothelial cell migration biological_process
GO:0018108 peptidyl-tyrosine phosphorylation biological_process
GO:0030307 positive regulation of cell growth biological_process
GO:0035924 cellular response to vascular endothelial growth factor stimulus biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043410 positive regulation of MAPKKK cascade biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0048010 vascular endothelial growth factor receptor signaling pathway biological_process
GO:0048514 blood vessel morphogenesis biological_process
GO:0060312 regulation of blood vessel remodeling biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0090037 positive regulation of protein kinase C signaling cascade biological_process
GO:0005576 extracellular region cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005021 vascular endothelial growth factor-activated receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0019838 growth factor binding molecular_function
GO:0019903 protein phosphatase binding molecular_function