fms-related tyrosine kinase 4

Symbol

FLT4 (may also be known as: None)

Organism

Human

Description

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
ver-1	Caenorhabditis elegans
flt4	Danio rerio
Flt4	Mus musculus
Flt4	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2714	Hypermethylation of FLT4 is positively correlated with age	Molecular	blood	Human	FLT4	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001934	positive regulation of protein phosphorylation	biological_process
GO:0001938	positive regulation of endothelial cell proliferation	biological_process
GO:0001944	vasculature development	biological_process
GO:0001945	lymph vessel development	biological_process
GO:0001946	lymphangiogenesis	biological_process
GO:0002040	sprouting angiogenesis	biological_process
GO:0006468	protein phosphorylation	biological_process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0010575	positive regulation vascular endothelial growth factor production	biological_process
GO:0010595	positive regulation of endothelial cell migration	biological_process
GO:0018108	peptidyl-tyrosine phosphorylation	biological_process
GO:0030307	positive regulation of cell growth	biological_process
GO:0035924	cellular response to vascular endothelial growth factor stimulus	biological_process
GO:0043066	negative regulation of apoptotic process	biological_process
GO:0043410	positive regulation of MAPKKK cascade	biological_process
GO:0046330	positive regulation of JNK cascade	biological_process
GO:0046777	protein autophosphorylation	biological_process
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological_process
GO:0048514	blood vessel morphogenesis	biological_process
GO:0060312	regulation of blood vessel remodeling	biological_process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological_process
GO:0090037	positive regulation of protein kinase C signaling cascade	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0016020	membrane	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0004713	protein tyrosine kinase activity	molecular_function
GO:0004714	transmembrane receptor protein tyrosine kinase activity	molecular_function
GO:0004872	receptor activity	molecular_function
GO:0005021	vascular endothelial growth factor-activated receptor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0016772	transferase activity, transferring phosphorus-containing groups	molecular_function
GO:0019838	growth factor binding	molecular_function
GO:0019903	protein phosphatase binding	molecular_function
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