filamin B, beta
Symbol
FLNB
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| Flnb | Mus musculus | |
| Flnb | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2798 | Gene expression of FLNB increases with age | Molecular | adipose tissue | Human | FLNB | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007016 | cytoskeletal anchoring at plasma membrane | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007517 | muscle organ development | biological_process | |
| GO:0007519 | skeletal muscle tissue development | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0030036 | actin cytoskeleton organization | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0001725 | stress fiber | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005925 | focal adhesion | cellular_component | |
| GO:0005938 | cell cortex | cellular_component | |
| GO:0015629 | actin cytoskeleton | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030018 | Z disc | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0042802 | identical protein binding | molecular_function | |