SMG1 phosphatidylinositol 3-kinase-related kinase

Symbol

SMG1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

Orthologs

SymbolSpecies
smg-1 Caenorhabditis elegans
Smg1 Drosophila melanogaster
smg1 Danio rerio
Smg1 Mus musculus
Smg1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3703 Gene expression of SMG1 increases with age Molecular skin Human SMG1 —

GO Terms

GO IDGO TermGO Category
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process
GO:0006281 DNA repair biological_process
GO:0006406 mRNA export from nucleus biological_process
GO:0006950 response to stress biological_process
GO:0010467 gene expression biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0018105 peptidyl-serine phosphorylation biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0046854 phosphatidylinositol phosphorylation biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function