forkhead box C1

Symbol

FOXC1 (may also be known as: None)

Organism

Human

Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
foxc1a Danio rerio
Foxc1 Mus musculus
Foxc1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001503 ossification biological_process
GO:0001541 ovarian follicle development biological_process
GO:0001568 blood vessel development biological_process
GO:0001570 vasculogenesis biological_process
GO:0001654 eye development biological_process
GO:0001656 metanephros development biological_process
GO:0001657 ureteric bud development biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001756 somitogenesis biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0001974 blood vessel remodeling biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006916 anti-apoptosis biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007420 brain development biological_process
GO:0007507 heart development biological_process
GO:0008354 germ cell migration biological_process
GO:0014032 neural crest cell development biological_process
GO:0014034 neural crest cell fate commitment biological_process
GO:0030199 collagen fibril organization biological_process
GO:0030203 glycosaminoglycan metabolic process biological_process
GO:0032808 lacrimal gland development biological_process
GO:0035050 embryonic heart tube development biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0043010 camera-type eye development biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045930 negative regulation of mitotic cell cycle biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046620 regulation of organ growth biological_process
GO:0048010 vascular endothelial growth factor receptor signaling pathway biological_process
GO:0048341 paraxial mesoderm formation biological_process
GO:0048343 paraxial mesodermal cell fate commitment biological_process
GO:0048762 mesenchymal cell differentiation biological_process
GO:0048844 artery morphogenesis biological_process
GO:0050880 regulation of blood vessel size biological_process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process
GO:0060038 cardiac muscle cell proliferation biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005720 nuclear heterochromatin cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function