forkhead box C1

Symbol

FOXC1 (may also be known as: None)

Organism

Human

Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
foxc1a Danio rerio
Foxc1 Mus musculus
Foxc1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2797 Gene expression of FOXC1 increases with age Molecular adipose tissue Human FOXC1 —

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001503 ossification biological_process
GO:0001541 ovarian follicle development biological_process
GO:0001568 blood vessel development biological_process
GO:0001570 vasculogenesis biological_process
GO:0001654 eye development biological_process
GO:0001656 metanephros development biological_process
GO:0001657 ureteric bud development biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001756 somitogenesis biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0001974 blood vessel remodeling biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006916 anti-apoptosis biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007420 brain development biological_process
GO:0007507 heart development biological_process
GO:0008354 germ cell migration biological_process
GO:0014032 neural crest cell development biological_process
GO:0014034 neural crest cell fate commitment biological_process
GO:0030199 collagen fibril organization biological_process
GO:0030203 glycosaminoglycan metabolic process biological_process
GO:0032808 lacrimal gland development biological_process
GO:0035050 embryonic heart tube development biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0043010 camera-type eye development biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045930 negative regulation of mitotic cell cycle biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046620 regulation of organ growth biological_process
GO:0048010 vascular endothelial growth factor receptor signaling pathway biological_process
GO:0048341 paraxial mesoderm formation biological_process
GO:0048343 paraxial mesodermal cell fate commitment biological_process
GO:0048762 mesenchymal cell differentiation biological_process
GO:0048844 artery morphogenesis biological_process
GO:0050880 regulation of blood vessel size biological_process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process
GO:0060038 cardiac muscle cell proliferation biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005720 nuclear heterochromatin cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0031490 chromatin DNA binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function