purinergic receptor P2X, ligand-gated ion channel, 2
Symbol
P2RX2
(may also be known as: None)
Organism
Human
Description
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| p2rx2 | Danio rerio | |
| P2rx2 | Mus musculus | |
| P2rx2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006812 | cation transport | biological_process | |
| GO:0010524 | positive regulation of calcium ion transport into cytosol | biological_process | |
| GO:0035590 | purinergic nucleotide receptor signaling pathway | biological_process | |
| GO:0050850 | positive regulation of calcium-mediated signaling | biological_process | |
| GO:0051260 | protein homooligomerization | biological_process | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0001614 | purinergic nucleotide receptor activity | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004931 | extracellular ATP-gated cation channel activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0015276 | ligand-gated ion channel activity | molecular_function | |
| GO:0042802 | identical protein binding | molecular_function | |