SREBF chaperone
Symbol
SCAP
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| scp-1 | Caenorhabditis elegans | |
| SCAP | Drosophila melanogaster | |
| scap | Danio rerio | |
| Scap | Mus musculus | |
| Scap | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001666 | response to hypoxia | biological_process | |
| GO:0006994 | positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway | biological_process | |
| GO:0007568 | aging | biological_process | |
| GO:0008202 | steroid metabolic process | biological_process | |
| GO:0008203 | cholesterol metabolic process | biological_process | |
| GO:0032868 | response to insulin stimulus | biological_process | |
| GO:0042304 | regulation of fatty acid biosynthetic process | biological_process | |
| GO:0045540 | regulation of cholesterol biosynthetic process | biological_process | |
| GO:0045541 | negative regulation of cholesterol biosynthetic process | biological_process | |
| GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0012507 | ER to Golgi transport vesicle membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0043234 | protein complex | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0051082 | unfolded protein binding | molecular_function | |