aldolase B, fructose-bisphosphate

Symbol

ALDOB (may also be known as: None)

Organism

Human

Description

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

Orthologs

SymbolSpecies
aldo-1 Caenorhabditis elegans
Ald Drosophila melanogaster
aldob Danio rerio
Aldob Mus musculus
Aldob Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2986 Gene expression of ALDOB increases with age Molecular skin Human ALDOB —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006000 fructose metabolic process biological_process
GO:0006001 fructose catabolic process biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006094 gluconeogenesis biological_process
GO:0006096 glycolysis biological_process
GO:0006116 NADH oxidation biological_process
GO:0030388 fructose 1,6-bisphosphate metabolic process biological_process
GO:0032781 positive regulation of ATPase activity biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly biological_process
GO:0005773 vacuole cellular_component
GO:0005815 microtubule organizing center cellular_component
GO:0005829 cytosol cellular_component
GO:0034451 centriolar satellite cellular_component
GO:0004332 fructose-bisphosphate aldolase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008092 cytoskeletal protein binding molecular_function
GO:0016829 lyase activity molecular_function
GO:0042802 identical protein binding molecular_function
GO:0051117 ATPase binding molecular_function
GO:0070061 fructose binding molecular_function