fructose-1,6-bisphosphatase 1

Symbol

FBP1 (may also be known as: None)

Organism

Human

Description

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
fbp1b Danio rerio
Fbp1 Mus musculus
Fbp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3132 Gene expression of FBP1 decreases with age Molecular skin Human FBP1 —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006000 fructose metabolic process biological_process
GO:0006002 fructose 6-phosphate metabolic process biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006094 gluconeogenesis biological_process
GO:0006111 regulation of gluconeogenesis biological_process
GO:0016311 dephosphorylation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0035690 cellular response to drug biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045820 negative regulation of glycolysis biological_process
GO:0046580 negative regulation of Ras protein signal transduction biological_process
GO:0051289 protein homotetramerization biological_process
GO:0071286 cellular response to magnesium ion biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005515 protein binding molecular_function
GO:0016208 AMP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function
GO:0042578 phosphoric ester hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0048029 monosaccharide binding molecular_function