aldehyde dehydrogenase 1 family, member A1

Symbol

ALDH1A1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Orthologs

SymbolSpecies
Aldh1a7 Rattus norvegicus
Aldh1a1 Mus musculus
Aldh1a1 Rattus norvegicus
Aldh1a7 Mus musculus
alh-1 Caenorhabditis elegans
alh-2 Caenorhabditis elegans
ALD4 Saccharomyces cerevisiae
ALD6 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2431 aldehyde dehydrogenase 1A1 decreases with age Molecular dermis Human ALDH1A1 30.3% Decrease DNA Methylation

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1721 aldehyde dehydrogenase family 1, subfamily A1 Molecular muscle Mouse Aldh1a1 6.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006069 ethanol oxidation biological_process
GO:0006081 cellular aldehyde metabolic process biological_process
GO:0006805 xenobiotic metabolic process biological_process
GO:0032320 positive regulation of Ras GTPase activity biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0001758 retinal dehydrogenase activity molecular_function
GO:0004029 aldehyde dehydrogenase (NAD) activity molecular_function
GO:0005099 Ras GTPase activator activity molecular_function
GO:0005497 androgen binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function