ets variant 6

Symbol

ETV6 (may also be known as: None)

Organism

Human

Description

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

Orthologs

SymbolSpecies
Etv6 Mus musculus
Etv6 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3126 Gene expression of ETV6 increases with age Molecular skin Human ETV6 —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0005634 nucleus cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function