EPH receptor B4

Symbol

EPHB4 (may also be known as: None)

Organism

Human

Description

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ephb4b Danio rerio
Ephb4 Mus musculus
Ephb4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3118 Gene expression of EPHB4 increases with age Molecular skin Human EPHB4 —

GO Terms

GO IDGO TermGO Category
GO:0001525 angiogenesis biological_process
GO:0002042 cell migration involved in sprouting angiogenesis biological_process
GO:0003007 heart morphogenesis biological_process
GO:0007155 cell adhesion biological_process
GO:0007275 multicellular organismal development biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0048013 ephrin receptor signaling pathway biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005003 ephrin receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function