epidermal growth factor receptor

Symbol

EGFR (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Orthologs

SymbolSpecies
Egfr Mus musculus
Egfr Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3113 Gene expression of EGFR increases with age Molecular skin Human EGFR —

GO Terms

GO IDGO TermGO Category
GO:0000902 cell morphogenesis biological_process
GO:0001503 ossification biological_process
GO:0001892 embryonic placenta development biological_process
GO:0001942 hair follicle development biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006950 response to stress biological_process
GO:0007165 signal transduction biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007202 activation of phospholipase C activity biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007411 axon guidance biological_process
GO:0007435 salivary gland morphogenesis biological_process
GO:0008283 cell proliferation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0016337 cell-cell adhesion biological_process
GO:0021795 cerebral cortex cell migration biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S biological_process
GO:0035413 positive regulation of catenin import into nucleus biological_process
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway biological_process
GO:0042177 negative regulation of protein catabolic process biological_process
GO:0042327 positive regulation of phosphorylation biological_process
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043406 positive regulation of MAP kinase activity biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0045739 positive regulation of DNA repair biological_process
GO:0045740 positive regulation of DNA replication biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0048146 positive regulation of fibroblast proliferation biological_process
GO:0048546 digestive tract morphogenesis biological_process
GO:0050679 positive regulation of epithelial cell proliferation biological_process
GO:0050730 regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0050999 regulation of nitric-oxide synthase activity biological_process
GO:0051205 protein insertion into membrane biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0060571 morphogenesis of an epithelial fold biological_process
GO:0070141 response to UV-A biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016323 basolateral plasma membrane cellular_component
GO:0030122 AP-2 adaptor complex cellular_component
GO:0030139 endocytic vesicle cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0070435 Shc-EGFR complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0004710 MAP/ERK kinase kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0004716 receptor signaling protein tyrosine kinase activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005006 epidermal growth factor-activated receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019903 protein phosphatase binding molecular_function
GO:0030235 nitric-oxide synthase regulator activity molecular_function
GO:0042802 identical protein binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0051015 actin filament binding molecular_function