E2F transcription factor 2
Symbol
Organism
Description
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| LOC568846 | Danio rerio | |
| E2f2 | Mus musculus | |
| LOC684111 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000080 | G1 phase of mitotic cell cycle | biological_process | |
| GO:0000278 | mitotic cell cycle | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0051726 | regulation of cell cycle | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005667 | transcription factor complex | cellular_component | |
| GO:0001047 | core promoter binding | molecular_function | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008134 | transcription factor binding | molecular_function | |