dedicator of cytokinesis 2
Symbol
DOCK2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| mbc | Drosophila melanogaster | |
| dock2 | Danio rerio | |
| Dock2 | Mus musculus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001766 | membrane raft polarization | biological_process | |
| GO:0001768 | establishment of T cell polarity | biological_process | |
| GO:0001771 | immunological synapse formation | biological_process | |
| GO:0006935 | chemotaxis | biological_process | |
| GO:0007010 | cytoskeleton organization | biological_process | |
| GO:0016032 | viral reproduction | biological_process | |
| GO:0030036 | actin cytoskeleton organization | biological_process | |
| GO:0045059 | positive thymic T cell selection | biological_process | |
| GO:0045060 | negative thymic T cell selection | biological_process | |
| GO:0046633 | alpha-beta T cell proliferation | biological_process | |
| GO:0050690 | regulation of defense response to virus by virus | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0012505 | endomembrane system | cellular_component | |
| GO:0005085 | guanyl-nucleotide exchange factor activity | molecular_function | |
| GO:0005525 | GTP binding | molecular_function | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0020037 | heme binding | molecular_function | |
| GO:0030675 | Rac GTPase activator activity | molecular_function | |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | molecular_function | |
| GO:0042608 | T cell receptor binding | molecular_function | |
| GO:0051020 | GTPase binding | molecular_function | |