decapping mRNA 2

Symbol

DCP2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Orthologs

SymbolSpecies
dcp2 Danio rerio
Dcp2 Mus musculus
Dcp2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4379 Gene expression of DCP2 increases with age Molecular skin Human DCP2 —

GO Terms

GO IDGO TermGO Category
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay biological_process
GO:0010467 gene expression biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay biological_process
GO:0071044 histone mRNA catabolic process biological_process
GO:0000932 cytoplasmic mRNA processing body cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0016442 RNA-induced silencing complex cellular_component
GO:0003723 RNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters molecular_function
GO:0030145 manganese ion binding molecular_function
GO:0046872 metal ion binding molecular_function