drebrin 1
Symbol
DBN1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| dbn1 | Danio rerio | |
| Dbn1 | Mus musculus | |
| Dbn1 | Rattus norvegicus | |
| app1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007015 | actin filament organization | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007399 | nervous system development | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0048168 | regulation of neuronal synaptic plasticity | biological_process | |
| GO:0050773 | regulation of dendrite development | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0015629 | actin cytoskeleton | cellular_component | |
| GO:0030425 | dendrite | cellular_component | |
| GO:0042641 | actomyosin | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0005522 | profilin binding | molecular_function | |