Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Symbol
DAB2
(may also be known as: None)
Organism
Human
Description
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| Dab2 | Mus musculus | |
| Dab2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000904 | cell morphogenesis involved in differentiation | biological_process | |
| GO:0001701 | in utero embryonic development | biological_process | |
| GO:0001934 | positive regulation of protein phosphorylation | biological_process | |
| GO:0006898 | receptor-mediated endocytosis | biological_process | |
| GO:0006907 | pinocytosis | biological_process | |
| GO:0007588 | excretion | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0030308 | negative regulation of cell growth | biological_process | |
| GO:0032091 | negative regulation of protein binding | biological_process | |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0045892 | negative regulation of transcription, DNA-dependent | biological_process | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
| GO:0090090 | negative regulation of canonical Wnt receptor signaling pathway | biological_process | |
| GO:2000096 | positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005905 | coated pit | cellular_component | |
| GO:0016324 | apical plasma membrane | cellular_component | |
| GO:0030665 | clathrin coated vesicle membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008022 | protein C-terminus binding | molecular_function | |