acyl-CoA wax alcohol acyltransferase 2

Symbol

AWAT2 (may also be known as: None)

Organism

Human

Description

This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

Orthologs

SymbolSpecies
CG1941 Drosophila melanogaster
Awat2 Mus musculus
Awat2 Rattus norvegicus
DGA1 Saccharomyces cerevisiae
dga1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0008610 lipid biosynthetic process biological_process
GO:0010025 wax biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity molecular_function