cytochrome P450, family 3, subfamily A, polypeptide 5
Symbol
Organism
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| Cyp3a13 | Mus musculus | |
| Cyp3a9 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006805 | xenobiotic metabolic process | biological_process | |
| GO:0008202 | steroid metabolic process | biological_process | |
| GO:0009822 | alkaloid catabolic process | biological_process | |
| GO:0042737 | drug catabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0070989 | oxidative demethylation | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0004497 | monooxygenase activity | molecular_function | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0016491 | oxidoreductase activity | molecular_function | |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | molecular_function | |
| GO:0019825 | oxygen binding | molecular_function | |
| GO:0020037 | heme binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0070330 | aromatase activity | molecular_function | |