cytochrome P450, family 1, subfamily B, polypeptide 1
Symbol
CYP1B1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| cyp1b1 | Danio rerio | |
| Cyp1b1 | Mus musculus | |
| Cyp1b1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001525 | angiogenesis | biological_process | |
| GO:0006725 | cellular aromatic compound metabolic process | biological_process | |
| GO:0006805 | xenobiotic metabolic process | biological_process | |
| GO:0007601 | visual perception | biological_process | |
| GO:0008210 | estrogen metabolic process | biological_process | |
| GO:0009404 | toxin metabolic process | biological_process | |
| GO:0009636 | response to toxin | biological_process | |
| GO:0010033 | response to organic substance | biological_process | |
| GO:0043542 | endothelial cell migration | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0061298 | retina vasculature development in camera-type eye | biological_process | |
| GO:0071603 | endothelial cell-cell adhesion | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0004497 | monooxygenase activity | molecular_function | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | molecular_function | |
| GO:0019825 | oxygen binding | molecular_function | |
| GO:0020037 | heme binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0070330 | aromatase activity | molecular_function | |