cytochrome b5 type A (microsomal)
Symbol
CYB5A
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| cyb5a | Danio rerio | |
| Cyb5a | Mus musculus | |
| Cyb5a | Rattus norvegicus | |
| CYB5 | Saccharomyces cerevisiae | |
| oca8 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006766 | vitamin metabolic process | biological_process | |
| GO:0006767 | water-soluble vitamin metabolic process | biological_process | |
| GO:0006810 | transport | biological_process | |
| GO:0019852 | L-ascorbic acid metabolic process | biological_process | |
| GO:0022900 | electron transport chain | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005741 | mitochondrial outer membrane | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0005792 | microsome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004033 | aldo-keto reductase (NADP) activity | molecular_function | |
| GO:0004129 | cytochrome-c oxidase activity | molecular_function | |
| GO:0019899 | enzyme binding | molecular_function | |
| GO:0020037 | heme binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |