cathepsin Z
Symbol
CTSZ
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| cpz-1 | Caenorhabditis elegans | |
| ctsz | Danio rerio | |
| Ctsz | Mus musculus | |
| Ctsz | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3081 | Gene expression of CTSZ decreases with age | Molecular | skin | Human | CTSZ | — | |
| DAA2703 | Hypomethylation of CTSZ is positively correlated with age | Molecular | blood | Human | CTSZ | — |
Changes associated with the orthologs of this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA1907 | cathepsin Z | Molecular | Anatomical System | Mouse | Ctsz | 11.0% Increase Gene Expression Level | |
| DAA1404 | cathepsin Z | Molecular | hippocampus | Mouse | Ctsz | 6.0% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006508 | proteolysis | biological_process | |
| GO:0060441 | epithelial tube branching involved in lung morphogenesis | biological_process | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0004197 | cysteine-type endopeptidase activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0008234 | cysteine-type peptidase activity | molecular_function | |