collagen, type IV, alpha 2

Symbol

COL4A2 (may also be known as: None)

Organism

Human

Description

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
col4a2 Danio rerio
Col4a2 Mus musculus
Col4a2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2791 Gene expression of COL4A2 decreases with age Molecular adipose tissue Human COL4A2 —

GO Terms

GO IDGO TermGO Category
GO:0006351 transcription, DNA-dependent biological_process
GO:0007411 axon guidance biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0071560 cellular response to transforming growth factor beta stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005581 collagen cellular_component
GO:0005587 collagen type IV cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0005201 extracellular matrix structural constituent molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function