collagen, type III, alpha 1

Symbol

COL3A1 (may also be known as: None)

Organism

Human

Description

This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Orthologs

SymbolSpecies
Wdr33 Mus musculus
Col3a1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3062 Gene expression of COL3A1 decreases with age Molecular skin Human COL3A1 —

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001568 blood vessel development biological_process
GO:0007160 cell-matrix adhesion biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007411 axon guidance biological_process
GO:0007507 heart development biological_process
GO:0009314 response to radiation biological_process
GO:0018149 peptide cross-linking biological_process
GO:0030168 platelet activation biological_process
GO:0030199 collagen fibril organization biological_process
GO:0032964 collagen biosynthetic process biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0042060 wound healing biological_process
GO:0043206 fibril organization biological_process
GO:0043588 skin development biological_process
GO:0048565 digestive tract development biological_process
GO:0050777 negative regulation of immune response biological_process
GO:0071230 cellular response to amino acid stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005581 collagen cellular_component
GO:0005586 collagen type III cellular_component
GO:0005615 extracellular space cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0005178 integrin binding molecular_function
GO:0005201 extracellular matrix structural constituent molecular_function
GO:0005515 protein binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0048407 platelet-derived growth factor binding molecular_function