chemokine (C-C motif) receptor 1

Symbol

CCR1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Ccr1 Mus musculus
Ccr1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2405 chemokine (C-C motif) receptor 1 decreases with age Molecular dermis Human CCR1 16.5% Decrease DNA Methylation
DAA2454 chemokine (C-C motif) receptor 1 increases with age Molecular mesenchymal stem cell Human CCR1 31.2% Increase DNA Methylation
DAA2303 chemokine (C-C motif) receptor 1 increases with age Molecular parietal lobe Human CCR1 53.9% Increase Gene Expression Level
DAA2297 chemokine (C-C motif) receptor 1 increases with age Molecular hippocampus Human CCR1 93.8% Increase Gene Expression Level
DAA2302 Chemokine (C-C motif) receptor 1 increases with age Molecular parietal lobe Human CCR1 129.2% Increase Gene Expression Level
DAA2296 Chemokine (C-C motif) receptor 1 increases with age Molecular hippocampus Human CCR1 182.5% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002407 dendritic cell chemotaxis biological_process
GO:0006816 calcium ion transport biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0006887 exocytosis biological_process
GO:0006935 chemotaxis biological_process
GO:0006954 inflammatory response biological_process
GO:0006955 immune response biological_process
GO:0007155 cell adhesion biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007267 cell-cell signaling biological_process
GO:0009611 response to wounding biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0030502 negative regulation of bone mineralization biological_process
GO:0045672 positive regulation of osteoclast differentiation biological_process
GO:0051928 positive regulation of calcium ion transport biological_process
GO:0070098 chemokine-mediated signaling pathway biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0004435 phosphatidylinositol phospholipase C activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004930 G-protein coupled receptor activity molecular_function
GO:0004950 chemokine receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016493 C-C chemokine receptor activity molecular_function
GO:0019957 C-C chemokine binding molecular_function
GO:0035717 chemokine (C-C motif) ligand 7 binding molecular_function
GO:0071791 chemokine (C-C motif) ligand 5 binding molecular_function