clathrin, light chain A
Symbol
CLTA
(may also be known as: None)
Organism
Human
Description
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| Clc | Drosophila melanogaster | |
| clta | Danio rerio | |
| Clta | Mus musculus | |
| Clta | Rattus norvegicus | |
| clc1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | biological_process | |
| GO:0006892 | post-Golgi vesicle-mediated transport | biological_process | |
| GO:0006897 | endocytosis | biological_process | |
| GO:0007173 | epidermal growth factor receptor signaling pathway | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0016044 | cellular membrane organization | biological_process | |
| GO:0016192 | vesicle-mediated transport | biological_process | |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | biological_process | |
| GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0030118 | clathrin coat | cellular_component | |
| GO:0030130 | clathrin coat of trans-Golgi network vesicle | cellular_component | |
| GO:0030132 | clathrin coat of coated pit | cellular_component | |
| GO:0030136 | clathrin-coated vesicle | cellular_component | |
| GO:0030659 | cytoplasmic vesicle membrane | cellular_component | |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0003674 | molecular_function | molecular_function | |
| GO:0005198 | structural molecule activity | molecular_function | |
| GO:0042277 | peptide binding | molecular_function | |