adaptor-related protein complex 2, sigma 1 subunit
Symbol
AP2S1
(may also be known as: None)
Organism
Human
Description
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| aps-2 | Caenorhabditis elegans | |
| AP-2sigma | Drosophila melanogaster | |
| ap2s1 | Danio rerio | |
| Ap2s1 | Mus musculus | |
| Ap2s1 | Rattus norvegicus | |
| APS2 | Saccharomyces cerevisiae | |
| aps2 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006810 | transport | biological_process | |
| GO:0006886 | intracellular protein transport | biological_process | |
| GO:0007173 | epidermal growth factor receptor signaling pathway | biological_process | |
| GO:0007268 | synaptic transmission | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0015031 | protein transport | biological_process | |
| GO:0016032 | viral reproduction | biological_process | |
| GO:0016192 | vesicle-mediated transport | biological_process | |
| GO:0030100 | regulation of endocytosis | biological_process | |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | biological_process | |
| GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
| GO:0048268 | clathrin coat assembly | biological_process | |
| GO:0050690 | regulation of defense response to virus by virus | biological_process | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005905 | coated pit | cellular_component | |
| GO:0030117 | membrane coat | cellular_component | |
| GO:0030122 | AP-2 adaptor complex | cellular_component | |
| GO:0030666 | endocytic vesicle membrane | cellular_component | |
| GO:0005215 | transporter activity | molecular_function | |
| GO:0008565 | protein transporter activity | molecular_function | |