V-set and immunoglobulin domain containing 4

Symbol

VSIG4 (may also be known as: None)

Organism

Human

Description

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Orthologs

SymbolSpecies
Vsig4 Mus musculus
Vsig4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3675 Gene expression of VSIG4 decreases with age Molecular skin Human VSIG4 —

GO Terms

GO IDGO TermGO Category
GO:0006957 complement activation, alternative pathway biological_process
GO:0032703 negative regulation of interleukin-2 production biological_process
GO:0042130 negative regulation of T cell proliferation biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0005515 protein binding molecular_function