vacuolar protein sorting 45 homolog (S. cerevisiae)
Symbol
VPS45
(may also be known as: None)
Organism
Human
Description
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| vps-45 | Caenorhabditis elegans | |
| Vps45 | Drosophila melanogaster | |
| vps45 | Danio rerio | |
| Vps45 | Mus musculus | |
| Vps45 | Rattus norvegicus | |
| VPS45 | Saccharomyces cerevisiae | |
| vps45 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2875 | Gene expression of VPS45 decreases with age | Molecular | adipose tissue | Human | VPS45 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | biological_process | |
| GO:0006904 | vesicle docking involved in exocytosis | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0016192 | vesicle-mediated transport | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0000299 | integral to membrane of membrane fraction | cellular_component | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005768 | endosome | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0010008 | endosome membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0003674 | molecular_function | molecular_function | |