chimerin 2
Symbol
CHN2
(may also be known as: None)
Organism
Human
Description
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| RhoGAP5A | Drosophila melanogaster | |
| chn2 | Danio rerio |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001675 | acrosome assembly | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007264 | small GTPase mediated signal transduction | biological_process | |
| GO:0035556 | intracellular signal transduction | biological_process | |
| GO:0043547 | positive regulation of GTPase activity | biological_process | |
| GO:0051056 | regulation of small GTPase mediated signal transduction | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0005070 | SH3/SH2 adaptor activity | molecular_function | |
| GO:0005096 | GTPase activator activity | molecular_function | |
| GO:0030675 | Rac GTPase activator activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |