protein tyrosine phosphatase, receptor type, T

Symbol

PTPRT (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ptprt Danio rerio
Ptprt Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2618 Hypomethylation of PTPRT is positively correlated with age Molecular blood Human PTPRT —

GO Terms

GO IDGO TermGO Category
GO:0006470 protein dephosphorylation biological_process
GO:0007155 cell adhesion biological_process
GO:0007156 homophilic cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0035335 peptidyl-tyrosine dephosphorylation biological_process
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004725 protein tyrosine phosphatase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008013 beta-catenin binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016790 thiolester hydrolase activity molecular_function
GO:0045294 alpha-catenin binding molecular_function
GO:0045295 gamma-catenin binding molecular_function
GO:0045296 cadherin binding molecular_function
GO:0051393 alpha-actinin binding molecular_function
GO:0070097 delta-catenin binding molecular_function