TRIO and F-actin binding protein

Symbol

TRIOBP (may also be known as: None)

Organism

Human

Description

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]

Orthologs

SymbolSpecies
CELE_F10G8.8 Caenorhabditis elegans
osp Drosophila melanogaster
si:ch211-133l11.8 Danio rerio
Triobp Mus musculus
Triobp Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0030047 actin modification biological_process
GO:0051016 barbed-end actin filament capping biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0015629 actin cytoskeleton cellular_component
GO:0003779 actin binding molecular_function
GO:0017049 GTP-Rho binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0045159 myosin II binding molecular_function