serine dehydratase
Symbol
SDS
(may also be known as: None)
Organism
Human
Description
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| LOC563642 | Danio rerio | |
| Sds | Mus musculus | |
| Sds | Rattus norvegicus | |
| YIL168W | Saccharomyces cerevisiae |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006094 | gluconeogenesis | biological_process | |
| GO:0006520 | cellular amino acid metabolic process | biological_process | |
| GO:0006565 | L-serine catabolic process | biological_process | |
| GO:0042866 | pyruvate biosynthetic process | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0003941 | L-serine ammonia-lyase activity | molecular_function | |
| GO:0004794 | L-threonine ammonia-lyase activity | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0030170 | pyridoxal phosphate binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |