bromodomain containing 8
Symbol
BRD8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| Brd8 | Drosophila melanogaster | |
| brd8 | Danio rerio | |
| Brd8 | Mus musculus | |
| Brd8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
| GO:0016568 | chromatin modification | biological_process | |
| GO:0040008 | regulation of growth | biological_process | |
| GO:0043967 | histone H4 acetylation | biological_process | |
| GO:0043968 | histone H2A acetylation | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0035267 | NuA4 histone acetyltransferase complex | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0004887 | thyroid hormone receptor activity | molecular_function | |