mucosa associated lymphoid tissue lymphoma translocation gene 1

Symbol

MALT1 (may also be known as: None)

Organism

Human

Description

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CELE_F22D3.6 Caenorhabditis elegans
malt1b Danio rerio
Malt1 Mus musculus
Malt1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3651 Gene expression of MALT1 increases with age Molecular skin Human MALT1 —

GO Terms

GO IDGO TermGO Category
GO:0002726 positive regulation of T cell cytokine production biological_process
GO:0006508 proteolysis biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006952 defense response biological_process
GO:0007250 activation of NF-kappaB-inducing kinase activity biological_process
GO:0016567 protein ubiquitination biological_process
GO:0031398 positive regulation of protein ubiquitination biological_process
GO:0032743 positive regulation of interleukin-2 production biological_process
GO:0042327 positive regulation of phosphorylation biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0050870 positive regulation of T cell activation biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051168 nuclear export biological_process
GO:0051259 protein oligomerization biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0032449 CBM complex cellular_component
GO:0043234 protein complex cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004197 cysteine-type endopeptidase activity molecular_function
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008233 peptidase activity molecular_function
GO:0019209 kinase activator activity molecular_function
GO:0043621 protein self-association molecular_function