aldehyde dehydrogenase 1 family, member L1
Symbol
ALDH1L1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| alh-3 | Caenorhabditis elegans | |
| Aldh1l1 | Mus musculus | |
| Aldh1l1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0009058 | biosynthetic process | biological_process | |
| GO:0009258 | 10-formyltetrahydrofolate catabolic process | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0000036 | acyl carrier activity | molecular_function | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0008168 | methyltransferase activity | molecular_function | |
| GO:0016155 | formyltetrahydrofolate dehydrogenase activity | molecular_function | |
| GO:0016491 | oxidoreductase activity | molecular_function | |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | molecular_function | |
| GO:0016742 | hydroxymethyl-, formyl- and related transferase activity | molecular_function | |
| GO:0048037 | cofactor binding | molecular_function | |