corin, serine peptidase
Symbol
CORIN
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG1632 | Drosophila melanogaster | |
| si:ch1073-76a20.1 | Danio rerio | |
| Corin | Mus musculus | |
| Corin | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0003050 | regulation of systemic arterial blood pressure by atrial natriuretic peptide | biological_process | |
| GO:0006508 | proteolysis | biological_process | |
| GO:0016486 | peptide hormone processing | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0009986 | cell surface | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0003824 | catalytic activity | molecular_function | |
| GO:0004252 | serine-type endopeptidase activity | molecular_function | |
| GO:0005044 | scavenger receptor activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0070008 | serine-type exopeptidase activity | molecular_function | |