tumor necrosis factor (ligand) superfamily, member 13b
Symbol
TNFSF13B
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| tnfsf13b | Danio rerio | |
| Tnfsf13b | Mus musculus | |
| Tnfsf13b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | biological_process | |
| GO:0002636 | positive regulation of germinal center formation | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0030890 | positive regulation of B cell proliferation | biological_process | |
| GO:0031295 | T cell costimulation | biological_process | |
| GO:0031296 | B cell costimulation | biological_process | |
| GO:0042102 | positive regulation of T cell proliferation | biological_process | |
| GO:0045885 | positive regulation of survival gene product expression | biological_process | |
| GO:0048305 | immunoglobulin secretion | biological_process | |
| GO:0050776 | regulation of immune response | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005625 | soluble fraction | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0005102 | receptor binding | molecular_function | |
| GO:0005125 | cytokine activity | molecular_function | |
| GO:0005164 | tumor necrosis factor receptor binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |