phosphomevalonate kinase

Symbol

PMVK (may also be known as: None)

Organism

Human

Description

This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]

Orthologs

SymbolSpecies
CELE_F32D8.13 Caenorhabditis elegans
CG10268 Drosophila melanogaster
pmvk Danio rerio
Pmvk Mus musculus
Pmvk Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3633 Gene expression of PMVK decreases with age Molecular skin Human PMVK —

GO Terms

GO IDGO TermGO Category
GO:0006695 cholesterol biosynthetic process biological_process
GO:0008299 isoprenoid biosynthetic process biological_process
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0070723 response to cholesterol biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005777 peroxisome cellular_component
GO:0005829 cytosol cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004631 phosphomevalonate kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016740 transferase activity molecular_function