transforming, acidic coiled-coil containing protein 2
Symbol
TACC2
(may also be known as: None)
Organism
Human
Description
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Tacc2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0021987 | cerebral cortex development | biological_process | |
| GO:0022008 | neurogenesis | biological_process | |
| GO:0022027 | interkinetic nuclear migration | biological_process | |
| GO:0030953 | astral microtubule organization | biological_process | |
| GO:0032886 | regulation of microtubule-based process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0005815 | microtubule organizing center | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0019904 | protein domain specific binding | molecular_function | |
| GO:0035257 | nuclear hormone receptor binding | molecular_function | |