1-acylglycerol-3-phosphate O-acyltransferase 1

Symbol

AGPAT1 (may also be known as: None)

Organism

Human

Description

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
agpat2 Danio rerio
Agpat1 Mus musculus
Agpat1 Rattus norvegicus
SPAC1851.02 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3627 Gene expression of AGPAT1 decreases with age Molecular skin Human AGPAT1 —

GO Terms

GO IDGO TermGO Category
GO:0001819 positive regulation of cytokine production biological_process
GO:0001961 positive regulation of cytokine-mediated signaling pathway biological_process
GO:0006112 energy reserve metabolic process biological_process
GO:0006644 phospholipid metabolic process biological_process
GO:0006654 phosphatidic acid biosynthetic process biological_process
GO:0008152 metabolic process biological_process
GO:0008654 phospholipid biosynthetic process biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0031325 positive regulation of cellular metabolic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function