protein C receptor, endothelial
Symbol
PROCR
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| Procr | Mus musculus | |
| Procr | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006955 | immune response | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0019882 | antigen processing and presentation | biological_process | |
| GO:0050819 | negative regulation of coagulation | biological_process | |
| GO:0005813 | centrosome | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0042612 | MHC class I protein complex | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |