ubiquitin-conjugating enzyme E2E 3
Symbol
UBE2E3
(may also be known as: None)
Organism
Human
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| ube2e3 | Danio rerio | |
| Ube2e3 | Mus musculus | |
| Ube2e3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0040008 | regulation of growth | biological_process | |
| GO:0070534 | protein K63-linked ubiquitination | biological_process | |
| GO:0070936 | protein K48-linked ubiquitination | biological_process | |
| GO:0070979 | protein K11-linked ubiquitination | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004842 | ubiquitin-protein ligase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |
| GO:0016881 | acid-amino acid ligase activity | molecular_function | |