CD2 (cytoplasmic tail) binding protein 2
Symbol
CD2BP2
(may also be known as: None)
Organism
Human
Description
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| teg-1 | Caenorhabditis elegans | |
| CG5198 | Drosophila melanogaster | |
| cd2bp2 | Danio rerio | |
| Cd2bp2 | Mus musculus | |
| Cd2bp2 | Rattus norvegicus | |
| SPBC83.09c | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000244 | assembly of spliceosomal tri-snRNP | biological_process | |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0010923 | negative regulation of phosphatase activity | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005682 | U5 snRNP | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0016607 | nuclear speck | cellular_component | |
| GO:0046540 | U4/U6 x U5 tri-snRNP complex | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0043021 | ribonucleoprotein complex binding | molecular_function | |