adenosine deaminase, RNA-specific, B1

Symbol

ADARB1 (may also be known as: None)

Organism

Human

Description

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
adarb1a Danio rerio
Adarb1 Mus musculus
Adarb1 Rattus norvegicus
TAD1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2981 Gene expression of ADARB1 increases with age Molecular skin Human ADARB1 —

GO Terms

GO IDGO TermGO Category
GO:0006382 adenosine to inosine editing biological_process
GO:0006396 RNA processing biological_process
GO:0006397 mRNA processing biological_process
GO:0010467 gene expression biological_process
GO:0016553 base conversion or substitution editing biological_process
GO:0016556 mRNA modification biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0003723 RNA binding molecular_function
GO:0003725 double-stranded RNA binding molecular_function
GO:0003726 double-stranded RNA adenosine deaminase activity molecular_function
GO:0003729 mRNA binding molecular_function
GO:0004000 adenosine deaminase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function