branched chain ketoacid dehydrogenase kinase
Symbol
BCKDK
(may also be known as: None)
Organism
Human
Description
The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| bckdk | Danio rerio | |
| Bckdk | Mus musculus | |
| Bckdk | Rattus norvegicus | |
| PKP1 | Saccharomyces cerevisiae |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0009063 | cellular amino acid catabolic process | biological_process | |
| GO:0009083 | branched chain family amino acid catabolic process | biological_process | |
| GO:0016310 | phosphorylation | biological_process | |
| GO:0018106 | peptidyl-histidine phosphorylation | biological_process | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005759 | mitochondrial matrix | cellular_component | |
| GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex | cellular_component | |
| GO:0000155 | two-component sensor activity | molecular_function | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016301 | kinase activity | molecular_function | |
| GO:0047323 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity | molecular_function | |